Covishield Vaccine, AstraZeneca's Acknowledgment of Rare Side Effects

Covishield Vaccine, AstraZeneca's Acknowledgment of Rare Side Effects

Apr 30 News Standard


With its AZD1222 Covid-19 vaccine, which is marketed as Covishield in India, AstraZeneca has disclosed a rare but severe side effect. This highlights growing concerns about thrombosis with thrombocytopenia syndrome (TTS). The corporation is being sued in the UK over vaccine-related health claims, and court filings from that country reveal this acknowledgement.


TTS symptoms can take many different forms. Some of these are headaches, numbness, skin bruising beyond the injection site, chest or limb pain, and dyspnea. These signs suggest that clotting may be limiting blood flow, which can result in serious consequences including heart attack or stroke. AstraZeneca's position on TTS in these documents highlights the intricacy of the matter, since it refutes a general connection between TTS and the vaccine while admitting a very uncommon correlation.

Regulatory Response

The rise of TTS-related issues leads to a review of previous cautions and measures. Prior to the Covid-19 vaccination program in India, the government sent out a warning statement recommending those with thrombocytopenia to administer Covishield with caution. In addition, AstraZeneca's vaccine was momentarily halted in Europe due to reports of blood clotting incidents. The World Health Organization (WHO) added its voice as well, noting that TTS post-vaccination does occur occasionally but highlighting the vaccine's general advantages.


To further advance our understanding of these uncommon yet dangerous side effects, the WHO additionally classified vaccine-induced immune thrombotic thrombocytopenia (VITT) inside its TTS classification in 2023. In order to support well-informed decision-making with Covid-19 vaccination, it is critical to strike a balance between the risks and benefits while maintaining open communication, as long as vaccine safety discussions continue.


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